Weight loss pill - Alli

For the first time, the U.S. Food and Drug Administration has approved an over-the-counter drug that's designed to block fat absorption in the body.

When combined with a healthy lifestyle, research shows Alli (orlistat) weight loss pill will boost weight loss by 50 percent.

"In real terms, that means if you would have lost 10 pounds with diet and physical activity, with diet, physical activity and Alli, you'll lose 15 pounds," says Gary Foster, Ph.D., an obesity researcher from Temple University in Philadelphia.

Alli works by blocking lipases, the enzymes that break down fat. The body excretes about 25 percent of the fat instead of absorbing it as calories. Users take the pills with meals.

The downside? About half the patients in clinical trials had loose stools or an oily discharge. Also, a month's supply could run as high as $60.

Wanda Hill is working on losing weight. She says she will not take weight loss pills to help her reach her goal. "When people begin to rely on a drug, what happens when you can no longer get that drug, or you can no longer afford that drug?"

Wanda is determined to shed 70 pounds the old fashioned way. She's counting calories and controlling her portions.

"To me it's a temporary thing -- a quick fix," she says of Alli.

But some disagree, saying Alli weight loss pill could live up to its name as a friend for those fighting fat. There are also many evidences that Alli really makes what it promises, and people even are ready to live along those side effects but have their body shedding extra pounds away effectively.

Alli is a reduced-strength version of the prescription drug orlistat. You're at highest risk for the side effects if you eat more than 15-grams of fat with your meals. Experts recommend taking a daily multivitamin like A, D, E and K to offset the loss of fat-soluble nutrients.

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Slimming pills - Alli and Proactol

Alli - arguable weight loss effects

For the first time, the Food and Drug Administration approved selling a prescription-only diet aid over the counter. Although Alli has been selling quickly, its "treatment effects" are controversial.

Alli, which went on sale June 15, is half as strong as its prescribed version, Xenical, said Brian Jones, the vice president of communications for GlaxoSmithKline, the manufacturer of Alli, in an e-mail interview.

According to an Alli brochure, the active ingredient, orlistat, prevents digestion of approximately 25 percent of fat consumed. Instead, it is released as "treatment effects," including gas, frequent bowel movements and oily discharge.

Effects are reduced if the fat intake for each meal is around 15 grams and calories remain low.

If Alli is used with diet and exercise, a person can "lose about 50 percent more weight than dieting alone," the brochure says.

Sheida Guilak, Cal State Fullerton graduate and pharmacy manager of Target in Fullerton, said Alli just "might give some people a jump start [in their diet]."

Jones defended Alli when asked about its possible abuse and said GlaxoSmithKline has been candid about treatment effects.

"Post-marketing surveillance recorded shows no signal of people with eating disorders finding any appeal in Alli. If you are not eating, there is no benefit; if you are binge eating, the treatment effects would be undesirable," Jones said.

But what about nasty treatment effects?

Senior Dustin Martinez, a kinesiology major at CSUF said peers in one of his classes take diet pills similar to Alli with warnings about "anal leakage," but they say these side effects do not happen to them.

When asked if he would recommend Alli to someone trying to lose weight Martinez said he would.

"Yeah, because if they're serious about a diet and they eat a lot of fast food, they'll learn the hard way. I think it will help them regulate their diet."

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